Why Medicines Must not be Taken with Grapefruit Juice?

🚫Do not drink medicine with grapefruit juice!!

🍊Grapefruit has a lot of nutrients and is one of my favorite fruits, but you have to be careful when taking medicines. Grapefruit contains a molecule to be aware of called bergamottin. Its name is derived from bergamot. It is also found in several citrus fruits such as pomelo and bitter orange.

🍊💊Bergamottin inhibits CYP3A4, an important enzyme in metabolism. As a result, the drug is not metabolized and maintains higher concentrations than necessary, which can lead to unexpected side effects. Particular attention should be paid to drugs that can be metabolized by CYP3A4, as shown in the following example.

 💊Calcium channel blocker (blood pressure-lowering medicine)

 💊Ciclosporin (Immunosuppressive drug)

 💊Triazolam (Sleeping pill)

There are many examples of drugs that grapefruit juice can cause problems.

Some statin drugs to lower cholesterol, such as Zocor (simvastatin) and Lipitor (atorvastatin).

Some drugs that treat high blood pressure, such as Procardia and Adalat CC (both nifedipine).

Some organ-transplant rejection drugs, such as Neoral and Sandimmune capsule or oral solution (both cyclosporine).

Some anti-anxiety drugs, such as BuSpar (buspirone).

Some corticosteroids that treat Crohn’s disease or ulcerative colitis, such as Entocort EC and Uceris tablet (both budesonide).

Some drugs that treat abnormal heart rhythms, such as Pacerone and Cordarone tablet (both amiodarone).

Some antihistamines, such as Allegra (fexofenadine).


💧Medicines are basically supposed to be taken with water. It is dangerous to take them with any other drinks.


1. National Institutes of Biomedical Innovation, Health and Nutrition, Japan

2. U.S. Food and Drug Administration (FDA)

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